Pratiwi, Kevin Hary (2013) Pengaruh ekstrak etanol daun sirsak (Annona muricata L.) terhadap gambaran histologi kelenjar mammae mencit (Mus musculus) yang di induksi 7,12-dimentilbenz(a)antrasen (DMBA) secara in vivo. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim.
|
Text (Introduction)
09620003 Pendahuluan.pdf Download (1MB) | Preview |
|
|
Text (Abstract: Indoensia)
09620003 Indonesia.pdf Download (135kB) | Preview |
|
|
Text (Abstract: English)
09620003 Inggris.pdf Download (139kB) | Preview |
|
|
Text (Abstract: Arabic)
09620003 Arab.pdf Download (82kB) | Preview |
|
|
Text (Chapter 1)
09620003 Bab 1.pdf Download (483kB) | Preview |
|
|
Text (Chapter 2)
09620003 Bab 2.pdf Download (1MB) | Preview |
|
|
Text (Chapter 3)
09620003 Bab 3.pdf Download (441kB) | Preview |
|
|
Text (Chapter 4)
09620003 Bab 4.pdf Download (668kB) | Preview |
|
|
Text (Chapter 5)
09620003 Bab 5.pdf Download (288kB) | Preview |
|
|
Text (References)
09620003 Daftar Pustaka.pdf Download (240kB) | Preview |
|
|
Text (Appendices)
09620003 Lampiran.pdf Download (1MB) | Preview |
Abstract
INDONESIA:
Daun Sirsak (Annona muricata L.) merupakan salah satu tanaman obat tradisional yang sering dimanfaatkan sebagai obat tradisional penyakit kanker. Daun sirsak mengandung bahan aktif acetogenins yang memiliki sifat sitotoksik terhadap sel kanker termasuk kanker payudara. Bahan aktif tersebut mampu mengendalikan mitokondria (organ sel penghasil energi) yang dibutuhkan sel kanker untuk berkembang. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun sirsak (Annona muricata L.) terhadap gambaran histologi kelenjar mammae mencit (Mus musculus) yang diinduksi 7,12-Dimethilbenz(α)Antrasen (DMBA) secara in vivo.
Penelitian ini bersifat eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan 6 perlakuan 4 kali ulangan. Perlakuan yang digunakan adalah (K-) kontrol negatif, (K+) kontrol positif, (P1) 100 mg/kg BB, (P2) 150 mg/kg BB, (P3) 200 mg/kg BB dan (P4) 250 mg/kg BB serta 7,12-Dimetilbenz(α)Antrasen (DMBA) 20 mg/kg BB. Hewan yang digunakan mencit betina sebanyak 24 ekor yang berumur ± 40 hari. Data hasil penelitian meliputi tebal epitel duktus mammae, tebal epitel alveoli mammae, diameter lumen duktus mammae, diameter lumen alveoli mammae mencit (Mus musculus). Data yang diperoleh dianalisis dengan ANOVA satu arah, apabila terdapat perbedaan sangat nyata maka dilanjutkan dengan uji duncan.
Hasil penelitian menunjukkan bahwa ekstrak daun sirsak (Annona muricata L.) berpengaruh terhadap histologi kelenjar mammae (Mus musculus). Penelitian ini memperlihatkan bahwa ekstrak daun sirsak (Annona muricata L.) berpengaruh terhadap proliferasi sel epitel duktus mammae dan sel epitel alveoli mammae ditemukan pada dosis 200 mg/kg BB, akan tetapi peningkatan proliferasi sel epitel duktus mammae dan sel epitel alveoli mammae serta sel epitel dijumpai pada dosis 100 mg/kg BB dan 150 mg/kg BB
ENGLISH:
Leaves soursop (Annona muricata L.) is one of the tradisional medicinal plants which are used as traditional medicine cancer. Soursop leaves containing active ingredients called acetogenins which have cytotoxic properties against cancer cells, including breadt cancer. The active ingredient is able to control mitochondria (producing energy organ cells) required for cancer cells to grow. This study aimed to determine the effect of ethanol extract of leaves of soursop (Annona muricata L.) on histological mammaey glands of mice (Mus musculus) induced 7,12-Dimetilbenz(α)Antrasen (DMBA) in vivo.
This is an experimental study using a completely randomized design (RAL) with 6 treatments 4 replications. The treatment used is the (K-) negative control, (K+) positive control, (P1) 100 mg / kg, (P2) 150 mg / kg, (P3) 200 mg / kg and (P4) 250 mg / kg and 7,12-Dimetilbenz(α)Antrasen (DMBA) 20 mg / kg BW. Animals used were 24 female mice tails ± 40 days old. Research data include mammary duct epithelium thick, thick alveolar epithelial mammary, mammary ductal lumen diameter, lumen diameter mammary alveoli of mice (Mus musculus). Data were analyzed by one-way ANOVA,where there is a very real difference then followed by Duncan test.
The results showed that the leaf extract of soursop (Annona muricata L.) effect on mammary gland histology (Mus musculus). This study showed that the leaf extract of soursop (Annona muricata L.) effect on the proliferation of mammary ductal epithelial cells and alveolar mammary epithelial cells was found at a dose of 200 mg / kg, but increased proliferation of mammary ductal epithelial cells and alveolar epithelial cells and mammary epithelial cells encountered at doses of 100 mg / kg and 150 mg / kg BW.
Item Type: | Thesis (Undergraduate) |
---|---|
Keywords: | Daun Sirsak (Annona muricata L.); Histologi Kelenjar Mammae; Mus musculus;Leaf Soursop (Annona muricata L.); Histology of the mammary gland; Mus musculus |
Subjects: | 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060807 Animal Structure and Function |
Departement: | Fakultas Sains dan Teknologi > Jurusan Biologi |
Depositing User: | Saputra Edi |
Date Deposited: | 28 Jul 2015 11:33 |
Last Modified: | 28 Jul 2015 11:33 |
URI: | http://etheses.uin-malang.ac.id/id/eprint/577 |
Downloads
Downloads per month over past year
Actions (login required)
![]() |
View Item |