Khalida, Nuzula Salsabiela (2019) Karakterisasi dan uji pelepasan mikroemulsi topikal natrium diklofenak menggunakan Virgin Coconut Oil (VCO) sebagai fase minyak. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim.
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Abstract
ENGLISH:
Diclofenac sodium is one of the non-steroidal anti-inflammatory drugs (NSAIDs) that is widely used to treat inflammation. On oral preparations, diclofenac sodium has side effects which can irritate the stomach. Because of these side effects, topical preparations are made. This study aims to determine the physicochemical characteristics and the effect of variations in the ratio of 15%, 20%, and 25% VCO concentrations to the release rate of diclofenac sodium topical microemulsions. Diclofenac sodium microemulsion is made by the emulsification method. The evaluation of the preparations observed included organoleptic, pH, type of microemulsion, particle size, physical stability, entrapment efficiency and release test. Diclofenac sodium microemulsions are clear liquid, transparent yellow, and stable at pH range of 5,7-5,9. Physical stability test results showed that the dosage was stable in storage at different temperature conditions, namely low temperature (4 ± 2°C), room temperature (28 ± 2°C), and high temperature (40 ± 2°C) for 4 weeks . The entrapment efficiency test results show that the amount of diclofenac sodium absorbed in the system is >80%. The results of the microemulsion particle size formula 1, 2, and 3 were 0,60 ± 0,3 nm respectively; 0,46 ± 0,2 nm; and 0,60 ± 0,4 nm. The highest release rate is shown in formula 2 which is 16,703 ± 0,731 μg/ cm2/ minute1/2.
INDONESIA:
Natrium diklofenak merupakan salah satu obat golongan nonsteroidal anti-inflammatory drug (NSAID) yang banyak digunakan untuk mengobati inflamasi. Pada sediaan oral, natrium diklofenak mempunyai efek samping yaitu dapat mengiritasi lambung. Oleh karena adanya efek samping tersebut, maka dibuat sediaan topikal. Penelitian ini bertujuan untuk mengetahui karakteristik fisikokimia dan pengaruh variasi perbandingan konsentrasi VCO 15%, 20%, dan 25% terhadap laju pelepasan mikroemulsi topikal natrium diklofenak. Mikroemulsi natrium diklofenak dibuat dengan metode emulsifikasi. Evaluasi sediaan yang diamati meliputi uji organoleptik, pH, tipe mikroemulsi, ukuran partikel, stabilitas fisik, efisiensi penjebakan dan uji pelepasan. Mikroemulsi natrium diklofenak berbentuk cairan jernih, berwarna kuning transparan, dan tidak mengalami pemisahan fase dengan rentang pH 5,7-5,9. Hasil uji stabilitas fisik menunjukkan bahwa sediaan stabil dalam penyimpanan pada kondisi suhu yang berbeda, yaitu suhu rendah (4 ± 2°C), suhu ruang (28 ± 2°C), dan suhu tinggi (40 ± 2°C) selama 4 minggu. Hasil uji efisiensi penjebakan menunjukkan bahwa jumlah natrium diklofenak yang terjerap dalam sistem >80%. Hasil ukuran partikel mikroemulsi formula 1, 2, dan 3 berturut-turut yaitu 0,60 ± 0,3 nm; 0,46 ± 0,2 nm; dan 0,60 ± 0,4 nm. Laju pelepasan tertinggi ditunjukkan pada formula 2 yaitu 16,703 ± 0,731 μg/cm2/menit1/2.
Item Type: | Thesis (Undergraduate) | |||||||||
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Supervisor: | Annisa, Rahmi and Indrawijaya, Yen Yen Ari | |||||||||
Contributors: |
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Keywords: | Natrium Diklofenak; Mikroemulsi; Virgin Coconut Oil (VCO); Pelepasan; Diclofenac Sodium; Microemulsion; Release Test | |||||||||
Departement: | Fakultas Sains dan Teknologi > Jurusan Farmasi | |||||||||
Depositing User: | Farahaqila Tami | |||||||||
Date Deposited: | 08 Apr 2020 16:56 | |||||||||
Last Modified: | 08 Apr 2020 16:56 | |||||||||
URI: | http://etheses.uin-malang.ac.id/id/eprint/16628 |
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