Nisa, Khairun (2017) Pengaruh pemberian ekstrak etanol 70% biji rambutan (Nephelium lappaceum L.) terhadap kenaikan kadar SOD dan penurunan kadar MDA pankreas mencit (Mus musculus) yang diinduksi streptozotocin. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim.
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Abstract
INDONESIA:
Biji Rambutan (Nephelium lappaceum L) merupakan tanaman yang dapat digunakan sebagai obat herbal, salah satunya sebagai antidiabetik. Biji Rambutan (Nephelium lappaceum L) diketahui memiliki senyawa fenol, flavonoid dan tanin. Senyawa dari golongan fenol, flavonoid dan tanin dapat memeperbaiki kondisi stres oksidatif pada diabetes yang ditandai dengan peningkatan SOD dan Penurunan kadar MDA.
Penelitian ini merupakan penelitian eksperimental yang menggunakan rancangan acak lengkap (RAL) dengan 6 perlakuan dan 4 ulangan. Pemberian Perlakuan ekstrak etanol 70% Biji Rambutan dengan P0 ( DM + CMC 0,5%), P1 (DM + EBR 15 mg/kgBB), P2 (DM+ EBR 19,2 mg/kgBB), P3 (DM+ EBR 23,4 mg/kgBB), K- (kontrol negatif) dan K+ (kontrol positif, metformin). Parameter penelitian ini meliputi kadar SOD dan MDA pankreas.
Berdasarkan hasil DMRT menunjukkan terdapat perbedaan antar perlakuan ekstrak etanol 70% Biji Rambutan (Nephelium lappaceum L) terhadap kadar SOD dan Analisis secara deskriptif terjadi penurunan terhadap kadar MDA. Dosis yang menunjukkan kadar SOD tertinggi dan kadar MDA terendah yaitu dosis 19,2 mg/kgBB
ENGLISH:
Rambutan seed (Nephelium lappaceum L) is a plant that can be used as herbal medicine, one of them is as an antidiabetic. Rambutan seed (Nephelium lappaceum L) is known to contain phenol, flavonoid and tannin compounds. Compounds of phenols, flavonoids and tannins group can repair the condition of oxidative stress in diabetes characterized by the increase of SOD level and the decline of MDA Level.
This research was experimental research by using a completely randomized design (RAL) with 6 treatments and 4 repetitions. The administration of 70% ethanol extract of Rambutan seed with P0 (DM + CMC 0.5%), P1 (DM + EBR 15 mg/kgBB), P2 (DM + EBR 19.2 mg/kgBB), P3 (DM + EBR 23.4 mg/kgBB), K- (negative control ) and K+ (positive control, metformin). The parameters of this study included the levels of SOD and MDA of pancreas.
Based on DMRT results showedthe existence of differences among all treatments of 70% ethanol extract of Rambutan seeds (Nephelium lappaceum L) on SOD level and in the descriptive analysis there was a decrease on MDA Level. The dose showing the highest SOD level and the lowest MDA level was the dose of 19.2 mg/kgBB.
Item Type: | Thesis (Undergraduate) | |||||||||
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Supervisor: | Susilowati, Retno and Syarifah, Umaiyatus | |||||||||
Contributors: |
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Keywords: | Etanol 70 %; Biji Rambutan (Nephelium lappaceum L); SOD; MDA; DM; streptozotocin; 70 % Ethanol; Rambutan seed (Nephelium lappaceum L) | |||||||||
Departement: | Fakultas Sains dan Teknologi > Jurusan Biologi | |||||||||
Depositing User: | Zuhria Sulkha Amalia | |||||||||
Date Deposited: | 10 Jul 2018 14:58 | |||||||||
Last Modified: | 10 Jul 2018 14:58 | |||||||||
URI: | http://etheses.uin-malang.ac.id/id/eprint/11692 |
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