Pengaruh pemberian bentuk sediaan pegagan (Centela asiantica (L.) urban) terhadap kadar superoksida dismutase (SOD) dan malondialdehide (MDA) otak tikus putih (Rattus norvegicus) betina yang diinduksi aloxan

Bahri, Samsul (2012) Pengaruh pemberian bentuk sediaan pegagan (Centela asiantica (L.) urban) terhadap kadar superoksida dismutase (SOD) dan malondialdehide (MDA) otak tikus putih (Rattus norvegicus) betina yang diinduksi aloxan. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim.

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Abstract

INDONESIA:

Tujuan penelitian ini adalah untuk mengetahui pengaruh bentuk sediaan pegagan (Centella asiantica (L.) Urban) dan lama pemberian bentuk sediaan pegagan (Centella asiantica (L.) Urban), serta untuk mengetahui interaksi antara bentuk sediaan pegagan (Centella asiantica (L.) Urban) terhadap kadar Superoksida dismutase (SOD dan kadar Malondialdehide (MDA) otak tikus putih (Rattus norvegicus) betina yang diinduksi aloksan.

Penelitian ini merupakan penelitian eksperimental yang menggunakan rancangan acak lengkap (RAL) pola faktorial yang terdiri atas 2 faktor dengan 3 kali ulangan. Faktor pertama dalam penelitian ini adalah sediaan daun pegagan yang terdiri atas 3 bentuk sediaan yaitu bentuk ekstrak, air rebusan dan segar. Faktor kedua adalah lama pemberian sediaan daun pegagan (28 hari dan 42 hari). Perlakuan dalam penelitian adalah tikus tanpa perlakuan (kontrol negatif), tikus nekrosis tanpa pemberian pegagan (kontrol positif), tikus nekrosis yang diberi ekstrak pegagan selama 28 hari dan 42 hari, tikus nekrosis yang diberi pegagan segar selama 28 hari dan 42 hari dan tikus nekrosis yang diberi air rebusan pegagan selama 28 hari dan 42 hari. Data yang diperoleh dianalisis menggunakan ANOVA Two Way. Apabila analisis menunjukkan pengaruh nyata, maka dilanjutkan dengan uji BNJ 1%.

Hasil penelitian ini menunjukkan bahwa pemberian berbagai bentuk sediaan pegagan berupa bentuk sediaan ekstrak, daun segar, dan air rebusan pegagan mampu meningkatkan kadar Superoksida dismutase (SOD) dan menghambat kadar Malondialdehide (MDA) otak tikus putih (Rattus norvegicus) betina yang diinduksi aloksan. Sedangkan lama pemberian pegagan (Centella asiantica (L.) Urban) 28 hari dan 42 hari, serta interaksi antara bentuk sediaan pegagan dan lama pemberian berpengaruh terhadap kadar Superoksida dismutase (SOD) dan kadar Malondialdehide (MDA) otak tikus putih (Rattus norvegicus) betina yang diinduksi alloxan.

ENGLISH:

The purpose of this study was to determine the effect of dosage forms gotu kola (Centella asiantica (L.) Urban) and duration of administration of the dosage form gotu kola (Centella asiantica (L.) Urban), and to investigate the interaction between dosage forms gotu kola (Centella asiantica (L.) Urban) on levels of Superoxide dismutase (SOD and the levels of Malondialdehyde (MDA) brain white rats (Rattus norvegicus) alloxan-induced females.

This study is an experimental study using completely randomized design (CRD) factorial pattern consisting of two factors with three replications. The first factor in this study is the preparation of gotu kola leaf consisting of three of the dosage form is the form of extracts, boiled water and fresh. The second factor is the duration of administration dosage of gotu kola leaf (28 days and 42 days). Treatment in the study were mice without treatment (negative control), rats without necrosis of gotu kola (positive control), rats fed extracts of Centella asiatica necrosis for 28 and 42 days, mice fed Centella asiatica fresh necrosis for 28 and 42 days and rats fed necrosis gotu kola boiling water for 28 and 42 days. The data obtained were analyzed using ANOVA Two Way. If the analysis shows the real effect, then continued with the test BNJ 1%.

The results of this study indicate that administration of various dosage forms dosage forms such as gotu kola extract, fresh leaves, and boiled water gotu kola can increase levels of Superoxide dismutase (SOD) and inhibit the levels of Malondialdehyde (MDA) brain white rats (Rattus norvegicus) alloxan-induced females. While the duration of gotu kola (Centella asiantica (L.) Urban) 28 days and 42 days, as well as the interaction between gotu kola dosage forms and duration of administration affect the levels of Superoxide dismutase (SOD) and the levels of Malondialdehyde (MDA) brain white rats (Rattus norvegicus) female alloxan induced.

Item Type: Thesis (Undergraduate)
Supervisor: Muchtaromah, Bayyinatul
Keywords: Pegagan (Centella asiantica (L.) Urban); SOD; MDA; Alloxan; dan Tikus Putih Betina; gotu kola (Centella asiatica (L.) Urban); SOD; MDA; Alloxan; and Rats White Females
Subjects: 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060806 Animal Physiological Ecology
Departement: Fakultas Sains dan Teknologi > Jurusan Biologi
Depositing User: Imam Rohmanu
Date Deposited: 04 Aug 2015 06:59
Last Modified: 04 Aug 2015 06:59
URI: http://etheses.uin-malang.ac.id/id/eprint/890

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