Pengaruh ekstrak air daun katu (Sauropus androgynus (L.) Merr.) terhadap berat uterus dan tebal endometrium mencit (Mus musculus L.) premenopause

Hikmah, Exma Mu'tatal (2014) Pengaruh ekstrak air daun katu (Sauropus androgynus (L.) Merr.) terhadap berat uterus dan tebal endometrium mencit (Mus musculus L.) premenopause. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim.

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Abstract

INDONESIA:

Menopause merupakan hal alami yang pasti terjadi. Premenopause merupakan fase sebelum terjadinya menopause yang merupakan bagian penting dalam pengkajian menopause. Salah satu keluhan yang muncul pada fase premenopause yaituadalah atrofi endometrium yang dapat menyebabkan terjadinya pendarahan pada endometrium. Daun katu diketahui mempunyai kandungan isoflavon yang bersifat estrogenik, yakni fitoestrogen yang diduga dapat memperbaiki keluhan pada wanita premenopause tersebut melalui ikatan dengan reseptor estrogen yang akan menginduksi terjadinya aktivitas proliferasi sel untuk penebalan endometrium dan peningkatan berat uterus. Tujuan penelitian ini adalah mengetahuipengaruhekstrak air daunkatudan dosis efektifnya terhadapberatuterusdan tebal endometrium mencit premenopause.

Penelitian ini merupakan penelitian eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan 5 ulangan. Hewan coba yang digunakan adalah mencit betina berusia 2 bulan 1 minggu berjumlah 20 ekor. Kondisi premenopause dilakukan dengan pemberian VCD (4-Vinyl cyclohexane dioxide). Kelompok perlakuan pada penelitian ini meliputi K- (normal), K+ (VCD+Ekstrak Air Daun Katu 0 mg/kgBB), P1 (VCD+Ekstrak Air Daun Katu 15 mg/kgBB) serta P2 (VCD+Ekstrak Air Daun Katu 30 mg/kgBB). Parameter yang diamati meliputi berat uterus dan tebal endometrium, selanjutnya dianalisis dengan One Way Anova 1%. Apabila terdapat perbedaan yang signifikan, maka di uji lanjut dengan BNT 1%. Selain itu juga dilakukan uji regresi linear dan uji Korelasi Pearson 1%.

Hasil penelitian menunjukkan bahwa pemberian ekstrak air daun katu berpengaruh terhadap berat uterus dan tebal endometrium serta korelasi antara keduanya adalah berkorelasi positif. Dosis yang paling efektif adalah pada kelompok P2 atau dosis 30 mg/kgBB dengan rata-rataberat uterus sebesar 112.80 mg dan tebal endometrium 342.40 μm.

ENGLISH:

Menopause constitutes a natural thing which is accurately happened. Premenopause constitutes phase before the happening of menopause which is as important part in the inspect of menopause. One of the complains appeared in the phase of premenopause is atrophy of endometrium which is capable of causing bleeding on endometrium. Katu leaf is known as having isoflavon uterus with estrogenic characterization, in which fitoestrogen is estimated as thing which is capable of fixing any complains withing women premenopause through the bond with estrogen receptor which will induct the happening of cell proliferation activity in order to thicken the endomentrium and increase the weight of uterus. This study aims to know the influences of the water extract of Katu leaf and the effective dosison the weight of uterus and the thickness of endometrium premenopausal mice.

This study constitute experimental research with complete random plan by 5 repetitions. The experimental animal used is 2 month-1 weak female mice in an amount of 20. The condition of premenopause done by giving VCD (4-Vinyl cyclohexane dioxide).A group of treatments toward this study includes K- (normal), K+ (VCD + the water extract of Katu leaf about 0 mg/kgBW), P1 (VCD+the water extract of Katu leaf 15 mg/kgBW) and P2 (VCD+the water leaf of Katu leaf 30 mg/kgBW). The observed parameter involved the weight of uterus and the thickness of endomentrium, then are analyzed with One way ANOVA 1%. If there is a significant difference, the further test will follow with BNT 1%. Besides, linear regression test is also performed and the Pearson correlation is also tested.

The result of the study shows that the given water extract of Katu leaf influenced on the weight of uterus and the thickness of endometrium and the correlation of the both of them are in the positive way. The most effective dosis in P2 group or dosis 30 mg/kgBW with the level of uterus weight about 112.80 mg and the endometrium thickness is 342.40 μm.

Item Type: Thesis (Undergraduate)
Supervisor: Susilowati, Retno and Ahmad, Mujahidin
Keywords: Premenopause; Ekstrak Air Daun Katu (Sauropus androgynus (L.) Merr.); Berat Uterus; Tebal Endometrium; Mencit (Mus musculus L.); the Water Extract of Katu leaf (Sauropus androgynus (L.) Merr.), the Weight of Uterus; the Thickness of Endometrium; Mice (Musmusculus L.)
Subjects: 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060803 Animal Developmental and Reproductive Biology
Departement: Fakultas Sains dan Teknologi > Jurusan Biologi
Depositing User: Dian Anesti
Date Deposited: 27 Jul 2015 01:47
Last Modified: 27 Jul 2015 01:47
URI: http://etheses.uin-malang.ac.id/id/eprint/508

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