Paduan getah pepaya (Carica papaya L.) Dan Polyvinyl Alcohol (PVA)-Glycolic Acid (GA) sebagai bahan baku benang jahit operasi yang absorbable

INDONESIA:

Benang jahit operasi yang dapat diserap (absorbable) umumnya memiliki kelemahan menimbulkan reaksi inflamasi, pemrosesan yang rumit, dan mahal. Masih sedikitnya industri yang memproduksi benang jahit operasi yang absorbable membuat Indonesia bergantung pada produk import. Sehingga perlu dikembangkan pembuatan benang jahit operasi yang absorbable dengan bahan getah pepaya untuk menutup luka. Benang jahit operasi yang absorbable dibuat dengan menggunakan campuran polivinil alkohol (PVA)-glycolic acid (GA) dan getah pepaya. Pembuatan sampel dilakukan dengan cara melarutkan polivinil alkohol dan glycolic acid kedalam aquades. Getah pepaya ditambahkan dengan konsentrasi 6.25; 7.5; 8.75; 10; 11.25; dan 12.5 (ml) dalam 25 ml PVA-GA. Campuran PVA-GA dan getah pepaya yang terbentuk dikarakterisasi menggunakan uji FT-IR, uji sifat mekanik, dan uji antibakteri. Hasil uji FTIR sampel menunjukkan adanya beberapa gugus fungsi antara lain gugus karbonil (C=O), gugus alkena (C=C), dan gugus hidroksil (O=H). Nilai kuat tarik tertinggi sebesar 41.05 Mpa pada konsentrasi getah pepaya 6.25 ml. Uji kelarutan lapisan tipis dalam NaCl 0.9% dapat larut secara perlahan sampai larut sempurna dalam waktu 2 hari. Diameter zona hambat yang terbentuk pada campuran getah pepaya dan PVA-GA tergolong sedang pada konsentrasi getah pepaya 6.25-11.25 (ml), sedangkan pada konsentrasi getah pepaya 12.5 ml , diameter zona hambat tergolong kuat.

ENGLISH:

The absorbable yarn sewing operations generally has weakness causing inflammatory reactions, complicated process and expensive. There are few the absorbable yarn sewing industry in Indonesia it gives impact on imported products. So it is necessary to develop the manufacture of absorbable suture with material of papaya gum to cover the wound. Absorbable suture was made using the mixture of polyvinyl alcohol (PVA)-glycolic acid (GA) and papaya gum. Sample preparation was done by dissolving polyvinyl alcohol and glycolic acid into distilled water. Papaya gums were added by concentration of 6.25; 7.5; 8.75; 10; 11.25; and 12.5 (ml) in 25 ml of PVA-GA. A mixture of PVA-GA and papaya gum formed were characterized using FT-IR test, test the mechanical properties, and anti-bacterial test. FTIR test results shown the presence of several functional groups included carbonyl (C=O), alkene (C=C), and the hydroxyl (O=H). The highest tensile strength value of papaya gum was 41.05 Mpa at a concentration of 6.25 ml. Solubility of thin layer into NaCl 0.9% can be dissolved slowly until completely dissolved reach within 2 days. Diameter of inhibition zone formed on a mix of papaya gum and PVA-GA was moderated in papaya gum concentration of 6.25-11.25 (ml), On the other side the inhibition zone diameter was wide in the concentration of papaya gum was 12.5 ml.