Raja, Damas (2022) NO PUBLISH Systematic literature review senyawa potensial anti-sars-cov-2 terhadap reseptor main protease melalui perspektif studi virtual screening in silico. Undergraduate thesis, Universitas Islam Negeri Maulana Malik Ibrahim.
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Abstract
ABSTRAK:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) merupakan sebuah virus RNA yang menyebabkan penyakit COVID-19. Virulensi yang tinggi dari virus ini dan kurangnya obat dengan mekanisme pasti pada virus, menyebabkan meluasnya penyakit COVID-19 hingga ditetapkan menjadi pandemi oleh WHO. Maka dari itu dilakukan penelitian dengan tujuan mencari bahan kimia yang berpotensi sebagai obat COVID-19 melalui hasil virtual screening in silico dengan mengetahui nilai binding affinity dan mekanisme antiviralnya. Metode yang digunakan dalam penelitian ini adalah systematic literature review dengan dua kata kunci dan empat database yaitu ScienceDirect, Spingerlink, Mandeley, dan PubMed yang kemudian dilakukan screening. Didapatkan 44 artikel lolos screening dari 187 artikel dengan hasil 109 senyawa dan 7 senyawa yang sering direkomendasikan oleh peneliti, yaitu Rutin, Quercetin, Myricetin, Indinavir, Nelfinavir, Danoprevir, dan Saquinavir. Sementara senyawa dengan binding affinity terendah adalah ZINC000015988935, ZINC000103558522, ZINC33173588, Lurasidone, ZINC03231196, ZINC12006217, Talampicilin, ZINC 32960814, Licofelone Acyl, dan Danoprevir. Binding affinity yang rendah memiliki arti kekuatan interaksi senyawa dan reseptor semakin kuat. Semua senyawa ini memiliki aktivitas Mpro / 3CLPro Inhibitor dengan mekanisme melakukan inhibisi yang menyebabkan terhambatnya replikasi virus dengan dilihat dari interaksi terhadap asam amino pada masing masing senyawa. Kedepanya perlu dilakukan penelitian secara In Vivo dan In Vitro untuk membuktikan aktivitas pada senyawa yang telah dihasilkan.
ABSTRACT:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an RNA virus that causes COVID-19. The high virulence of this virus and the lack of a drug with a definite mechanism on the virus, caused the spread of the COVID-19 disease until it was declared a pandemic by WHO. Therefore, a study was conducted with the aim of finding chemicals that have the potential as COVID-19 drugs through the results of virtual screening in silico by knowing the binding affinity value and antiviral mechanism. The method used in this study was a systematic literature review with two keywords and four databases, namely ScienceDirect, Spingerlink, Mandeley, and PubMed which were then screened. There were 44 articles that passed the screening from 187 articles with the results of 109 compounds and 7 compounds that are often recommended by researchers, namely Rutin, Quercetin, Myricetin, Indinavir, Nelfinavir, Danoprevir, and Saquinavir. Meanwhile, the compounds with the lowest binding affinity were ZINC000015988935, ZINC000103558522, ZINC33173588, Lurasidone, ZINC03231196, ZINC12006217, Talampicilin, ZINC 32960814, Licofelone Acyl, and Danoprevir. Low binding affinity means that the strength of the interaction between the compound and the receptor is getting stronger. All of these compounds have Mpro / 3CLPro Inhibitor activity with the mechanism of inhibition which causes inhibition of viral replication by looking at the interaction with the amino acids in each compound. In the future, it is necessary to conduct in vivo and in vitro studies to prove the activity of the compounds that have been produced.
مستخلص البحث:
انوروك سوريف2 ( ةميخولا ةداحلا ةيسفنتلا ةمزلاتملل ببسملاSARS-CoV-2 وه ) سوريفRNA يذلا ضرم ببسيCOVID-19 سوريفلا اذهل ةيلاعلا ةوارضلا تثدح . ضرم راشتنا ثدح امك ،هيف ةددحم تايلآ تاذ ةيودأ دوجو مدعوCOVID-19 مت ىتح لبق نم ءابو هنأ ىلع هديدحتWHO نع ثحبلا ءارجإ مت ،اذل .ةيملاعلا ةحصلا ةمظنم قلا اهيدل يتلا ةيئايميكلا داوملا جلاع ىلع ةردCOVID-19 يضارتفلاا صحفلا جئاتن للاخ in silico ةقيرطلا .تاسوريفلل ةداضملا هتيلآو براقتلا طبر ةميق ةفرعم قيرط نع عبرأو نيتيساسأ نيتملكب ةيجهنملا ةقباسلا تاساردلا ةعجارم يه ثحبلا اذه يف ةمدختسملا يأ تانايب دعاوقScienceDirect وSpingerlink وMandeley وPubMed يتلاو كلذ دعب اهصحفب موقت. نأ لصاحلا44 نم صحفلا تزاتجا ةلاقم781 جئاتن عم ةلاقم721 و تابكرم1 يه ،نوثحابلا اهب يصوي ام ابلاغ تابكرمRutin ،Quercetin ، Myricetin ،Indinavir ،Nelfinavir ،Danoprevir و ،Saquinavir تابكرملا امأ . راقت ىندأ اهل يهف طابترلاا بZINC000015988935 وZINC000103558522 و ZINC33173588 وLurasidone وZINC03231196 وZINC12006217 و Talampicilin وZINC 32960814 وLicofelone Acyl وDanoprevir . هذه عيمج .تلابقتسملاو تابكرملا نيب لعافتلا ةوق دادزت نأ ينعي طابترلاا براقت ضافخنا ا طاشن اهل تابكرملMpro / تاطبثم3CLPro رثاكتلا طيبثت ببست طيبثت اهتيلآو نم ،دعب اميفو .بكرم لك يف ةينيملأا ضامحلأا عم لعافتلا نم مكحلا للاخ نم يسوريفلا لكشب ثحبلا ءارجإ يرورضلاIn Vivo وIn Vitro يتلا تابكرملا ىلع طاشنلا تابثلإ .اهجاتنإ مت
Item Type: | Thesis (Undergraduate) | |||||||||
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Supervisor: | Muti'ah, Roihatul and Firman Firdausy, Alif | |||||||||
Contributors: |
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Keywords: | SLR; Virtual Screening In Silico; COVID-19 SLR; Virtual Screening In Silico; COVID-19 LR ;وكيليس يف يضارتفلاا صحفلا ;COVID-19 | |||||||||
Departement: | Fakultas Sains dan Teknologi > Jurusan Farmasi | |||||||||
Depositing User: | Damas Raja | |||||||||
Date Deposited: | 27 Aug 2024 13:10 | |||||||||
Last Modified: | 27 Aug 2024 13:10 | |||||||||
URI: | http://etheses.uin-malang.ac.id/id/eprint/38419 |
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SYSTEMATIC LITERATURE REVIEW SENYAWA POTENSIAL ANTI-SARS-CoV-2 TERHADAP RESEPTOR Main Protease MELALUI PERSPEKTIF STUDI VIRTUAL SCREENING IN SILICO. (deposited UNSPECIFIED)
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